Your favorite cold and flu medicine may soon go missing from shelves.

In a move following others to regulate materials without previous approval by the Food and Drug Administration, about 500 medicines will be pulled from shelves, the FDA announced Wednesday.

The Star Tribune reports FDA officials say they had received reports of adverse effects, like irritability and over-sedation but are unsure how widely products like Lordrane and Cardac are used being they are not household names.

Manufacturers have 90 days to stop making the affected products and 180 to cease shipping.